Grapevine Genetic and Genomic Group (*English*)

De Mendoza CONICET


GRAPEVINE GENETIC AND GENOMIC GROUP / Genética y Genómica de Vid (*Español*)

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Research lines

Our group is interested in understanding the genetic and molecular mechanisms of the grapevine, responsible for the regulation of different traits related to the grape and wine quality. In particular our work focuses on: i) studying the genetic control of the anthocyanins profiles in grape skin; ii) the molecular and genetic analysis of stilbene synthase gene family (STS) that regulates the production of resveratrol; and iii) the study of genes involved in determining the size and shape of the berry.

Our approach is based on characterizing and exploiting the grapevine natural genetic variation for these traits using genetic and genomic tools. To this end, we collaborate with other groups in the characterization and genetic analysis of different materials (grapevine varieties, wild accessions, clones, somatic variants and mapping populations). In addition, we participate in the development and application of new genomic analysis tools such as molecular markers (SNPs and SSRs) and microarrays to analyze global gene expression.

The generation of this knowledge has direct application to the selection of clones and varieties with new productive features. Moreover, the developed tools have wide application for genetic identification as well as for monitoring the grape development or the response to different environmental or culture conditions.

Group members

  • Diego Lijavetzky - Research scientist (CONICET) (Principal investigator)
  • Claudio Muñoz - Postgraduate fellow (CONICET)
  • Constanza Soledad Chialva - Postgraduate fellow (CONICET)
  • Cecilia Grissi - Postgraduate fellow (CONICET)

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  • INTA Mendoza (Sebastian Gomez Talquenca, Melisa Lanza Volpe, Rocío Torres)
  • Grupo de Fotobiología IBAM (Carina Gonzalez, Hernán E Boccalandro)
  • Instituto de la Ciencia de la Vid y el Vino-Logroño, España (José Miguel Martinez Zapater, Javier Ibañez, Pablo Carbonell Bejerano)
  • Universidad de Murcia, España (Mª Angeles Pedreño, Lorena Almagro)



  • Carbonell-Bejerano, P, Santa Maria, E, Torres-Perez, R, Royo, C, LIJAVETZKY, D, Bravo, G, Aguirreolea, J, Sanchez-Diaz, M, Antolin, MC and Martinez-Zapater, JM. 2013: Thermotolerance Responses in Ripening Berries of Vitis vinifera L. cv Muscat Hamburg. Plant Cell Physiol. doi: 10.1093/pcp/pct071.


  • LIJAVETZKY D, Carbonell Bejerano P, Grimplet P, Bravo G, Flores P, Fenoll J, Hellín P, Oliveros JC, Martínez Zapater JM. 2012: Berry Flesh and Skin Ripening Features in Vitis vinifera as Assessed by Transcriptional Profiling. PLoS ONE 7(6): e39547. doi:10.1371/journal.pone.0039547
  • Belchí-Navarro S, Almagro L, LIJAVETZKY D, Bru R and Pedreño MA. 2012: Enhanced extracellular production of trans-resveratrol in Vitis vinifera suspension cultured cells by using cyclodextrins and methyljasmonate. Plant Cell Reports 31, 81-89


  • Cabezas J, Ibanez J, LIJAVETZKY D, Velez D, Bravo G, Rodriguez V, Carreno I, Jermakow A, Carreno J, Ruiz-Garcia L, Thomas M, Martinez-Zapater J. 2011: A 48 SNP Set for Grapevine Cultivar Identification. BMC Plant Biology 11, 153.
  • Martínez-Esteso MJ, Sellés-Marchart S, LIJAVETZKY D, Pedreño MA and Bru-Martínez R: A DIGE-based quantitative proteomic analysis of grape berry flesh development and ripening reveals key events in sugar and organic acid metabolism. Journal of Experimental Botany 2011, 62, 2521-2569


  • Pontin MA, Piccoli PN, Francisco R, Bottini R, Martinez-Zapater JM and LIJAVETZKY D: Transcriptome changes in grapevine (Vitis vinifera L.) cv. Malbec leaves induced by ultraviolet-B radiation. BMC Plant Biology 2010, 10:224.
  • Martinez-Zapater JM, Carmona MJ, Díaz-Riquelme J, Fernández L and LIJAVETZKY D: Grapevine Genetics after the Genome Sequence: Challenges and Limitations. Australian Journal of Grape Wine Research 2010, 16(s1):33-46.
  • MUÑOZ C, Gómez Talquenca S, Oriolani E, Combina M. Genetic characterization of grapevine-infecting Botrytis cinerea isolates from Argentina. Revista Iberoamericana de Micología 2010, 27:66-70.


  • Gómez Talquenca S, MUÑOZ C, Grau O, Gracia O. First description of Grapevine leafroll-associated virus 5 in Argentina and partial genome sequence. Virus Genes 2009, 38:184-186.
  • Diaz-Riquelme J#, LIJAVETZKY , D#, Martinez-Zapater JM, Carmona MJ: Genome-Wide Analysis of MIKCC-Type MADS-Box Genes in Grapevine. Plant Physiology 2009, 149:354-369. #Equal contributors.
  • MUÑOZ C, Gómez Talquenca S, Volpe ML. Tetra primer ARMS-PCR for identification of SNP in [beta]-tubulin of Botrytis cinerea, responsible of resistance to benzimidazole. Journal of Microbiological Methods 2009, 78:245-246.


  • LIJAVETZKY D#, Almagro L#, Belchi-Navarro S, Martinez-Zapater JM, Bru R, Pedreno MA: Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures. BMC Research Notes 2008, 1:132. #Equal contributors
  • MUÑOZ C, Gomez Talquenca S, Oriolani E, Arias F. Identificación rápida de distintas razas de Botrytis cinerea en cultivos de vid. Enología.(5):24.


  • LIJAVETZKY D, Cabezas JA, Ibanez A, Rodriguez V, Martinez-Zapater JM: High throughput SNP discovery and genotyping in grapevine (Vitis vinifera L.) by combining a re-sequencing approach and SNPlex technology. BMC Genomics 2007, 8:424.
  • Peng FY, Reid KE, Liao N, Schlosser J, LIJAVETZKY D, Holt R, Martinez-Zapater JM, Jones S, Marra M, Bohlmann J, Lund ST: Generation of ESTs in Vitis vinifera wine grape (Cabernet Sauvignon) and table grape (Muscat Hamburg) and discovery of new candidate genes with possible roles in berry development. Gene 2007, 402:40-50.


  • LIJAVETZKY D, Ruiz-Garcia L, Cabezas JA, De Andres MT, Bravo G, Ibanez A, Carreno J, Cabello F, Ibanez J, Martinez-Zapater JM: Molecular genetics of berry colour variation in table grape. Mol Genet Genomics 2006, 276:427-435.


  • LIJAVETZKY D, Carbonero P, Vicente-Carbajosa J: Genome-wide comparative phylogenetic analysis of the rice and Arabidopsis Dof gene families. BMC Evolutionary Biology 2003, 3.
  • Helguera M, Khan IA, Kolmer J, LIJAVETZKY D, Zhong-qi L, Dubcovsky J: PCR assays for the Lr37-Yr17-Sr38 cluster of rust resistance genes and their use to develop isogenic hard red spring wheat lines. Crop Science 2003, 43:1839-1847.
  • Carrari F, Benech-Arnold R, Osuna-Fernandez R, Hopp E, Sanchez R, Iusem N, LIJAVETZKY D: Genetic mapping of the Sorghum bicolor vp1 gene and its relationship with pre-harvest sprouting resistance. Genome 2003, 46:253-258.
  • Carrari F, Perez-Flores L, LIJAVETZKY D, Enciso S, Sanchez R, Benech-Arnold R, Iusem N: Cloning and expression of a sorghum gene with homology to maize vp1. Its potential involvement in pre-harvest sprouting resistance. Plant Molecular Biology 2001, 45:631-640.
  • Carrari F, Frankel N, LIJAVETZKY D, Benech-Arnold R, Sanchez R, Iusem ND: The Tata-less promoter of VP1, a plant gene controlling seed germination. DNA Sequence 2001, 12:107-114.
  • LIJAVETZKY D, Martinez MC, Carrari F, Hopp HE: QTL analysis and mapping of pre-harvest sprouting resistance in sorghum. Euphytica 2000, 112:125-135.
  • Tranquilli G, LIJAVETZKY D, Muzzi G, Dubcovsky J: Genetic and physical characterization of grain texture-related loci in diploid wheat. Molecular and General Genetics 1999, 262:846-850.
  • LIJAVETZKY D, Muzzi G, Wicker T, Keller B, Wing R, Dubcovsky J: Construction and characterization of a bacterial artificial chromosome (BAC) library for the A genome of wheat. Genome 1999, 42:1176-1182.
  • Dubcovsky J, LIJAVETZKY D, Appendino L, Tranquilli G: Comparative RFLP mapping of Triticum monococcum genes controlling vernalization requirement. Theoretical and Applied Genetics 1998, 97:968-975.
  • Rossi M, LIJAVETZKY D, Bernacchi D, Hopp HE, Iusem N: Asr genes belong to a gene family comprising at least three closely linked loci on chromosome 4 in tomato. Molecular & General Genetics 1996, 252:489-492.

Funded projects

  • Candidate gene analysis in the determination of grapevine fruit size. 06/A594. Biennial projects 2011-2013. SeCTyP-UNCUYO. (PI: Diego Lijavetzky)
  • Characterization of grapevine clones using genomic and biochemical tools. Scientific and technological collaboration funded by Catena-Zapata winery (Bodegas Esmeralda S.A.). (PI: Diego Lijavetzky)
  • Characterization of grapevine cultivars and clones using genomic tools. ES/09/07. Scientific & Technological Cooperation Programme MINCYT (Argentina) y MICINN (Spain). (PI: Diego Lijavetzky)
  • Genetic regulation of resveratrol accumulation in grapevine. Natural genetic variation and response to different stress. PAE-PICT-02360. National Agency for the Promotion of Science and Technology. (PI: Diego Lijavetzky)
  • Use and development of genomic and transcriptomic tools for the characterization and study of grapevine (Vitis vinifera) cultivars and clones. PRH-PICT2008-00270. National Agency for the Promotion of Science and Technology. (PI: Diego Lijavetzky)
  • Generation, transfer and broadcasting of scientific and technological knowledge to strengthen the sustainability and competitiveness of Argentina's viticulture and wine industry. PAE2006. National Agency for the Promotion of Science and Technology. (PI: Rubén Bottini)
  • Functional genomics in the elicitation of plant cell cultures for the production of compounds with anti-tumor activity. FUNDACION SENECA. Murcia. (PI: María Angeles Pedreño García)



Instituto de Biología Agrícola de Mendoza (IBAM-CONICET)

Facultad de Ciencias Agrarias-UNCuyo

Almirante Brown 500 - (5505)

Chacras de Coria, Mendoza, Argentina

Tel: +54 261 4135010 Ext. 1307

FAX: +54 261 4960469




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